Hunt HB, Miller NA, Hemmerling KJ, et al. - Researchers assume that progressive glycemic derangement alters microscale bone tissue composition. Fourier‐transform infrared imaging was applied to examine the composition of iliac crest biopsies from cohorts of postmenopausal women defined by oral glucose tolerance testing: normal glucose tolerance (normal glucose tolerance; n = 35, age = 65 ± 7 years, HbA1c = 5.8 ± 0.3%), impaired glucose tolerance (IGT; n = 26, age = 64 ± 5 years, HbA1c = 6.0 ± 0.4%), and overt type 2 diabetes mellitus on insulin (n = 25, age = 64 ± 6 years, HbA1c = 9.13 ± 0.6). This study’s findings demonstrate progressive alteration of bone tissue composition with worsening glycemic control in humans.