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Bone structure assessed with pQCT in prepubertal males with delayed puberty or congenital hypogonadotropic hypogonadism

Clinical Endocrinology Mar 24, 2021

Varimo T, Miettinen J PJ, Laine T, et al. - A cross‐sectional study was conducted to present bone structure in congenital hypogonadotropic hypogonadism (CHH) patients and compares it to that in boys with constitutional delay of growth and puberty (CDGP). Researchers conducted the peripheral quantitative computed tomography of the non‐dominant arm and left leg in five treatment‐naïve males diagnosed with CHH and in 24 males with CDGP. They assessed volumetric bone mineral density (BMD), bone mineral content, and area in trabecular and cortical bone compartments, and bone age‐adjusted Z‐scores for the bone parameters were ascertained. It was shown that five treatment‐naïve male patients with CHH exhibited poorer trabecular BMD than untreated males with CDGP. The study further demonstrates that low‐dose sex steroid replacement in CHH males may benefit skeletal health in adulthood.

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