Donze SH, et al. - Experts sought to examine the effects of growth hormone (GH) vs placebo in GH-treated young adults with Prader-Willi syndrome (PWS) who had attained adult height (AH). In addition, they investigated the effects of sex steroid replacement therapy (SSRT), on bone mineral density (BMD) among these patients. In young adults with PWS, 1 year of placebo after attainment of AH did not deteriorate BMD SDS compared to GH treatment. Findings also suggested that unless GH was combined with SSRT, it was not able to prevent the decline in BMD SDS in hypogonadal young adults with PWS.