Salman-Monte TC, et al. - This study analyzed the literature data on the prevalence and predictors of reduced vitamin D plasma levels, bone loss and the presence of fractures in systemic lupus erythematosus (SLE) patients. Findings suggested a multifactorial etiology of reduced bone mass and reduced vitamin D plasma levels in SLE patients, which incorporates disease-related intrinsic factors as well as treatment side effects. These patients are prone to develop reduced vitamin D plasma levels and low Bone Mineral Density (BMD) and hence should be monitored and treated for bone metabolism disorders.