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Bone mineral density and body composition in children with congenital adrenal hyperplasia

Clinical Endocrinology Jun 09, 2018

Halper A, et al. - Researchers pursued a comparison of bone mineral density (BMD) and body composition, including visceral adipose tissue (VAT) and Android:Gynoid (A:G) ratio, in children with congenital adrenal hyperplasia (CAH) vs healthy age-matched, sex-matched and BMI-matched controls. For this analysis, 42 cases with CAH and 101 controls underwent a dual-energy X-ray absorptiometry scan. Compared with controls, lower BMD was observed in CAH cases. No differences in body composition were identified. It was observed in the findings that increased chronic androgen exposure, as measured by bone age Z-scores, was linked with higher BMD but was not correlated with VAT among CAH cases.
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