Yang J, et al. - As an increase in the reports regarding the bone metastasis of gastrointestinal stromal tumor (GIST) has been noted with the prolonged survival of patients with GISTs, researchers intended to better understand GISTs, and therefore, they performed this inquiry including 45 patients (mean age = 61.09 years) with bone metastases of GIST. The literature associated with the bone metastasis of GIST was identified from the Cochrane and Medline database (via PubMed). The bony metastases most commonly involved spine. The mean survival time following the GIST diagnosis was documented to be more than 64.02 months. A worse prognosis was experienced by patients younger than 60 years old vs those older than 60 years old. A worse prognosis was also seen in those with spinal involvement vs those without spinal involvement. A better prognosis was promised by surgical interventions integrated with targeted therapies. Overall, findings revealed a rather rare occurrence of bone metastasis of GIST. A more frequent as well as earlier suffering from bone metastasis was reported in patients who encountered GISTs of the small intestine and stomach vs those having GISTs in other primary sites. The factors that may potentially influence the prognosis of GIST patients with bone metastases were: age, gender, primary tumor location, treatment mode for the primary lesions and metastases, and spine involvement.