Vogel T, Wendler J, Frank-Raue K, et al. - In this retrospective cohort study involving 1,060 medullary thyroid carcinoma (MTC) patients, researchers described the prevalence of bone metastases (BM), frequency of skeletal related events (SREs), and effect of BM morphology and SREs on prognosis, as well as evaluated the role of antiresorptive treatment (ART). This research was carried out at four German referral centers. In total, 120 of 416 individuals (29%) with metastatic MTC had BM, of which 97% had concurrent nonosseous metastases. The presence of osteolytic metastases was associated with impaired overall survival but no incidence of SREs. BM occurs most often in metastatic MTC with an osteolytic morphology and an adverse prognosis. Most SREs are found in osteolytic metastases, and ART can prevent them.