Joo YS, Nam KH, Jhee JH, et al. - In this study, body weight fluctuations were shown to be significantly linked with an elevated risk of rapid kidney function decline in individuals with normal kidney function.

• From the Korean Genome and Epidemiology Study, data from 6,790 participants were analyzed to assess the impacts of body weight fluctuations on renal function deterioration in a prospective cohort of people with normal kidney function.

• Fluctuations in body weight were assessed via average successive variability (ASV), which was defined as the average absolute body weight change using repeated measurements for all participants.

• On dividing participants into tertiles by ASV, a greater prevalence of rapid estimated glomerular filtration rate (eGFR) decline was noted in the highest ASV tertile group than in the lowest.

• With multiple logistic regression, it was evident that risk of rapid eGFR decline was elevated in the highest ASV tertile group vs the lowest (odds ratio: 1.66).