Oh TJ, et al. - In this study involving a Korean population from the Korean Genome and Epidemiology Study, researchers investigated whether body-weight fluctuation is associated with incident diabetes mellitus, cardiovascular events, and mortality. Based on their results, they noted an association of body-weight fluctuation with mortality. They also observed that the effect of body-weight fluctuation on incident diabetes mellitus depended on baseline obesity.

Methods

• Researchers calculated the intraindividual fluctuations of body weight by average successive variability (ASV).
• Study participants included 3,678 individuals, among whom the investigators recorded health-related outcomes every 2 years for 16 years.

Results

• According to the findings, participants with a high body weight ASV were more obese and had higher baseline blood pressure levels and HbA1c than those with a low body weight ASV.
• Furthermore, a 1-unit increase in ASV of body weight was linked to increase in mortality (HR, 1.46; 95% CI: 1.32-1.62; P < 0.001).
• However, they noted that the association of body weight ASV with incident diabetes mellitus was influenced by baseline BMI: a negative effect in those with BMI < 25 kg/m² (HR, 1.36; 95% CI: 1.11-1.65; P=0.003) and a protective effect in those with BMI ≥ 25 kg/m² (HR, 0.76; 95% CI: 0.60-0.95; P=0.014).
• No association was found between the ASV of body weight and cardiovascular event.