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Body weight and eGFR during dulaglutide treatment in type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7)

Diabetes, Obesity and Metabolism Feb 21, 2019

Tuttle KR, et al. - In this post hoc analysis, researchers investigated whether lesser eGFR decline with dulaglutide is related to body weight (BW) loss. They found that BW decreased with dulaglutide 1.5 mg and 0.75 mg and increased with insulin glargine. Furthermore, changes in eGFR were not significant with dulaglutide 1.5 mg and 0.75 mg; however, eGFR significantly decreased with insulin glargine. Overall, BW loss did not impact the lesser decline observed in eGFR with dulaglutide.

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