Yuan Y, Chu C, Zheng WL, et al. - Utilizing a dataset with 30 years of follow-up in northern China, researchers identified distinct BMI trajectories across the life-course and analyzed the impacts of BMI trajectories on the adult cardiovascular disease outcomes. The sample consisted of 2,839 candidates (aged 6 to 18 years) whose BMIs were measured 3-6 times during the Hanzhong Adolescent Hypertension Study. The latent mixed models identified three groups with distinct trajectories in the BMI: a low-increasing group (n = 1,324), a moderate-increasing group (n = 1,178), and a high-increasing group (n = 337). The risk ratios of hypertension, T2DM, high-risk triglycerides, and high-risk high-density lipoprotein cholesterol were more than 3.0 in the high-increasing group after being fully adjusted compared with the candidates in the low-increasing group. According to findings, BMI trajectories vary from childhood to adulthood, and that an elevated early life BMI trajectory suggests an increased risk of developing cardiovascular disease risks.