Louca P, Nogal A, Mompeo O, et al. - In this study, not only the role of body mass index (BMI) in the mechanisms whereby the DASH (Dietary Approaches to Stop Hypertension) diet impacts hypertension was emphasized but also common metabolic pathways were highlighted.

• This study involved 2,424 females from the cross-sectional TwinsUK cohort.

• BMI completely mediated the relationship between the DASH diet and hypertension, explaining 39.1% of the variance in hypertension.

• Experts discovered a panel of six common metabolites predicting both the DASH diet and BMI with opposing impacts.

• Metabolites, at the univariate level, were also related to hypertension in the same direction as BMI.

• 1-nonadecanoyl-GPC (19:0) (the strongest feature) showed positive correlation with the DASH diet and negative correlation with BMI and hypertension (odds ratio = 0.71).