Alam NN, Wright AK, Rutter MK, et al. - In type 2 diabetes patients, some associations between body mass index (BMI) and cancer mortality were found in this study, however, interpretations required to account for smoking status, reverse causality, and deaths from cardiovascular disease (CVD).

• This study included an incident type 2 diabetes cohort (N: 176,886; aged 30-85 years), in which BMI ±12 months diabetes diagnosis was determined.

• A total of 7,593 cancer deaths occurred over 886,850 person years of follow-up.

• Positive links between BMI and deaths due to endometrial (hazard ratio per 5 kg/m ² : 1.43) were evident in females who never smoked.

• In males, the links between BMI and obesity-related cancer mortality were found to be inverse but attenuated towards null in never smokers and excluding deaths in the first 2 years.

• Men exhibited increase in the proportion of CVD deaths from 36.8% in BMI category 22.5 to 24.9 kg/m ² to 43.6% in BMI category ≥ 40 kg/m ² .