Rivas-Garcia TE, et al. - Whether plasma-borne zinc (Zn), a key ion in neuroplasticity, can be associated with the severity of functional, psychological and cognitive impairment in non-demented older individuals, was investigated using a complete battery of geriatric and psychometric tests. A possible role of peripheral Zn concentration in the physiopathology of some domain of cognitive function was suggested. Peripheral Zn concentration did not correlate with depressive symptoms in the geriatric population under antidepressant drug treatment. Depressive symptoms were found to be related to poor sleep quality and polymedication.