Tangen IL, et al. - Authors evaluated the association of levels of steroids in blood and prognosis for endometrial cancer (EC) patients. They assessed the plasma levels of 19 steroids using liquid-chromatography tandem mass-spectrometry in 38 postmenopausal EC patients. In these patients, several of the identified plasma steroids were encouraging biomarkers. Compared to subcutaneous fat, in this population visceral fat is a larger contributor to estradiol production, as indicated by the association between increased estradiol levels and a high percentage of visceral fat. A significant increase in the plasma steroid levels for DHEA, DHEAS, progesterone, 21 OH progesterone and E1S was seen in patients with long survival vs short.