Tangen IL, et al. - As endometrial cancer (EC) is a hormone dependent cancer, researchers sought the relation between level of steroids in blood and prognosis for EC patients investigating plasma levels of 19 steroids using liquid-chromatography tandem mass-spectrometry in 38 postmenopausal EC patients, 19 with long, and 19 with short survival. Patients with long survival displayed significantly increased plasma levels for dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulphate (DHEAS), progesterone (P4), 21OH-progesterone (21OH-P4) and estrone-sulphate (E1S) than those with short survival. Findings revealed increased estradiol levels to be associated with a high percentage of visceral fat indicating visceral fat to be a greater contributor to estradiol production vs subcutaneous fat in this population.