Forsse D, Tangen IL, Fasmer KE, et al. - Researchers evaluated the potential utility of a clinically available method of steroid hormone measurement for prognosis in endometrial cancer. Hundred endometrial cancer patients from a prospective cohort were assessed for seven steroid hormones using liquid chromatography-tandem mass spectrometry. Abdominal CT scans yielded data on abdominal fat distribution. The analysis revealed aggressive tumor characteristics in correlation to low 17OH-progesterone, 11-deoxycortisol and androstenedione. They identified 17OH-progesterone and 11-deoxycortisol as relevant for predicting poor survival irrespective of preoperative risk classification. Tumors of patients with high steroid levels were enriched with genes associated with estrogen signaling.