Delgado J, et al. - This study encompassed the determination of individual patient blood pressure (BP) for each of the 20 years before death. In addition, authors evaluated the potential mechanisms that could elucidate trajectories. The findings revealed a decrease in the mean systolic BP (SBP) and diastolic BP (DBP) for more than a decade before death in patients dying at 60 years and older. Such BP decreases were not merely due to age, treatment of hypertension, or better survival without hypertension. Late-life BP decreases could exhibit implications for risk estimation, treatment monitoring and trial design.