Riva-Posse P, et al. - Given that ketamine infusions for depression cause small and transient increases in blood pressure, researchers here examined the cardiovascular safety of ketamine when administered at subanesthetic doses to treat depression. Findings revealed small blood pressure changes when ketamine was administered over 40 minutes at 0.5 mg/kg for the treatment of depression. The changes were, however, well tolerated and clinically insignificant.