Yano Y, Reis JP, Lewis CE, et al. - A prospective cohort study was conducted to ascertain whether the long-term variability of BP across clinical visits and the rate of change in blood pressure (BP) from young adulthood to midlife are correlated with cardiovascular disease (CVD) and all-cause mortality by middle age, independently of mean BP during young adulthood and a single BP in midlife. They recruited a community-based sample of 3,394 African American and white individuals in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, between March 1985 and June 1986. They analyzed patterns of systolic BP (SBP) with measurements at year 0 (baseline) and 2, 5, 7, and 10 years after baseline. They collected data between March 1985 and August 2015 and examined from June through October 2019. By using Cox proportional hazards regression models, they determined the correlation of each SBP pattern with CVD events and all-cause mortality. Results suggested that the evaluation of visit-to-visit systolic blood pressure variability may help identify young adults at raised risk for CVD and all-cause mortality.