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Blood pressure and cardiovascular disease in older patients with diabetes: Retrospective cohort study

Journal of the American Heart Association Nov 06, 2021

Hong S, Park JH, Han K, et al. - A large sample of older Korean patients with diabetes was examined and more common occurrences of cardiovascular events were observed in relation to resting systolic blood pressure (SBP) or diastolic blood pressure (BP) ≥140 or 95 mm Hg, respectively, in these people. Also, those with resting SBP or diastolic BP <120 or 65 mm Hg, respectively, more commonly suffered cardiovascular events in this sample.

  • There is lack of clarity on BP targets in elderly patients with diabetes.

  • Using the National Health Information Database, this retrospective cohort study included 225,563 elderly (aged ≥65 years) patients with diabetes without cardiovascular disease or heart failure from 2009 to 2017.

  • Multivariable Cox proportional hazard modeling revealed a U‐curved association between the risk of the primary outcome (stroke, myocardial infarction, heart failure, and all‐cause death) and SBP/diastolic BP with a nadir between 120 and 129 mm Hg/65 and 69 mm Hg, respectively.

  • Lower risk of primary composite outcomes in SBP ≥140 mm Hg and diastolic blood pressure ≥90 mm Hg was observed in relation to hypertension medication.

  • SBP ≥160 mm Hg, in those aged ≥80 years, was only a marginally higher risk for primary composite outcomes (hazard ratio=1.11).

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