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Blood biomarkers associated with inflammation predict poor prognosis in cerebral venous thrombosis

European Journal of Neurology Oct 12, 2020

de Sousa DA, Pereira‐Santos MC, Serra‐Caetano A, et al. - Among patients with cerebral venous thrombosis (CVT), researchers investigated if blood biomarkers of inflammation were related to the evolution of brain lesions, persistent venous occlusion or functional outcome in a multicenter prospective cohort study. In patients with CVT, elevated interleukin‐6 levels were higher, with a peak at baseline. A significant link of IL‐6, neutrophil‐to‐lymphocyte ratio (NLR) and C‐reactive protein (CRP) levels with unfavorable functional outcome at 90 days was observed, but not with brain lesion outcomes or early recanalization. Experts concluded the likely utility of raised baseline levels of NLR, CRP and IL‐6 as novel predictive markers of worse functional prognosis at 90 days in patients with CVT. Findings revealed that there was no link between inflammatory markers and early evolution of brain lesion or venous recanalization.

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