Gyanwali B, Lai MKP, Lui B, et al. - Since cardiac biomarkers, NT-proBNP (N-terminal probrain natriuretic peptide), hs-cTnT (high-sensitivity-cardiac troponin T), and GDF-15 (growth differentiation factor-15) have been proposed as important biomarkers of early vascular pathology, but little is known about the longitudinal associations of these cardiac biomarkers with cerebrovascular disease and clinical events, researchers sought to investigate the correlation of blood-based cardiac biomarkers (NT-proBNP, hs-cTnT, and GDF-15) with cognitive decline, incident cerebrovascular disease, vascular events, and mortality. Four hundred thirty-four memory-clinic patients provided baseline blood samples, underwent 3 annual neuropsychological assessments and had brain MRI scans at baseline and follow-up. Higher levels of blood-based cardiac biomarkers were linked to decline in memory and risk of vascular events and mortality. Furthermore, NT-proBNP and hs-cTnT were related to incident cerebral microbleeds and cortical infarcts. As a result, these biomarkers can be useful in recognizing patients who are at risk of vascular events and death.