Arba F, Piccardi B, Palumbo V, et al. - This study was undertaken to determine if pre-treatment blood-brain-barrier (BBB) leakage is correlated with subsequent hemorrhagic transformation (HT) in patients with acute ischemic stroke treated with reperfusion therapy. Patients with acute ischemic stroke treated with intravenous thrombolysis and/or endovascular treatment were prospectively screened. The authors recruited 171 patients with an available assessment of BBB leakage, mean (± SD) age 75.5 (± 11.8) years, 86 (50%) males, and median (IQR) National Institutes of Health Stroke Scale of 18 (12-23). Pre-treatment BBB leakage prior to reperfusion therapy was linked to HT and may aid in identifying patients at risk of HT.