Meloni A, Righi R, Missere M, et al. - A retrospective/cohort study A retrospective/cohort study was performed to develop the ranges for normal left ventricular (LV) and right ventricular volumes and ejection fraction and LV mass normalized to body surface area (BSA), age, and gender in a large cohort of well‐treated beta‐thalassemia major (β‐TM) patients without heart damage using a multiparametric MRI. This research enrolled 251 β‐TM patients with no known risk factors or cardiac disease, normal electrocardiogram, no macroscopic myocardial fibrosis, and all cardiac segments with T2* ≥20 msec, and 246 healthy subjects. Researchers conducted comparisons between the two groups with two‐samples t‐test or Wilcoxon's signed rank test. One‐way analysis of variance or a Kruskal–Wallis test were applied for more than two groups. The results of this study reveal that appropriate “normal” reference ranges normalized to BSA, gender, and age are recommended to avoid misdiagnosis of cardiomyopathy in β‐TM patients.