Bivalirudin with a post-procedure infusion vs heparin monotherapy for the prevention of stent thrombosis
Catheterization and Cardiovascular Interventions Jan 17, 2019
Shah R, et al. - Researchers assessed the effectiveness of bivalirudin infusion at full dose after percutaneous coronary intervention (PCI) vs heparin monotherapy to prevent stent thrombosis (ST). For this purpose, they performed a meta-analysis of four relevant randomized controlled trials involving 13,505 patients. They also used random effect models to estimate risk ratios (RRs). They primarily focused on the risk of early definite ST. Findings revealed that a 55% decrease in the risk of early definite ST (RR: 0.45, 95% confidence interval: 0.23–0.85; P = 0.015) was observed in association with the use of bivalirudin (with a post-procedure infusion) vs heparin monotherapy.
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