Birth outcomes between 22 and 26 weeks' gestation in national population-based cohorts from Sweden, England and France
Acta Pediatrica Sep 16, 2021
Morgan AS, Zeitlin J, Källén K, et al. - Despite controlling for background factors, differences in survival and morbidity outcomes for extremely preterm births are observed. There was no clear link found between early mortality and subsequent morbidity trends.
EXPRESS (Sweden, 2004–07), EPICure-2 (England, 2006) and EPIPAGE-2 (France, 2011) cohort data were harmonised.
At 22–23 weeks’ GA, 112-day survival was 28.2%, 10.8% and 0.5% for 769 EXPRESS, 2310 EPICure-2 and 1359 EPIPAGE-2 foetuses; 68.5%, 40.0% and 23.6% for 24 weeks; 80.5%, 64.8% and 56.9% at 25 weeks; and 86.6%, 77.1% and 74.4% for 26 weeks.
EPIPAGE-2 death rates were highest before 1 day at 22–23 and 24 weeks GA.
Survival varied before 28 days at 25 weeks; changes at 26 weeks were minor.
Cox analyses were compatible with the Kaplan-Meier analyses. Morbidity variations were not strongly connected with survival.
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