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Birth outcomes between 22 and 26 weeks' gestation in national population-based cohorts from Sweden, England and France

Acta Pediatrica Sep 16, 2021

Morgan AS, Zeitlin J, Källén K, et al. - Despite controlling for background factors, differences in survival and morbidity outcomes for extremely preterm births are observed. There was no clear link found between early mortality and subsequent morbidity trends.

  • EXPRESS (Sweden, 2004–07), EPICure-2 (England, 2006) and EPIPAGE-2 (France, 2011) cohort data were harmonised.

  • At 22–23 weeks’ GA, 112-day survival was 28.2%, 10.8% and 0.5% for 769 EXPRESS, 2310 EPICure-2 and 1359 EPIPAGE-2 foetuses; 68.5%, 40.0% and 23.6% for 24 weeks; 80.5%, 64.8% and 56.9% at 25 weeks; and 86.6%, 77.1% and 74.4% for 26 weeks.

  • EPIPAGE-2 death rates were highest before 1 day at 22–23 and 24 weeks GA.

  • Survival varied before 28 days at 25 weeks; changes at 26 weeks were minor.

  • Cox analyses were compatible with the Kaplan-Meier analyses. Morbidity variations were not strongly connected with survival.

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