Li X, Chen Y, Xie Y, et al. - The decline pattern and possible determinants of beta-cell function progression were examined in patients with adult-onset latent autoimmune diabetes (LADA). Among a total of 106 LADA individuals, annual follow up was performed in this 8-year prospective study. Fasting C-peptide (FCP) < 75 pmol/L defined beta-cell function failure. Development of beta-cell function failure was reported in 28.7% individuals. The decline pattern of C-peptide was a “fast followed by slow” biphasic mode. About a quarter of LADA showed development of beta-cell function failure in the first 8 years’ duration. For the preservation of beta-cell function, they identified GADA titer less than 173.5 WHO units ⁄mL as propitious