Picca A, Coelho-Junior HJ, Calvani R, et al. - According to findings from this study, metabolic, hematologic, and inflammatory biomarkers are shared between frailty and sarcopenia. Common pathophysiological mechanisms are suggested by the biomarkers shared between the two conditions.

• This is a systematic review and meta-analysis of cross-sectional and longitudinal studies examining the link of frailty and/or sarcopenia with biomarkers as a primary or secondary outcome in adults aged 60 years and older.

• A total of 80 eligible studies (58 on frailty and 22 on sarcopenia) were included from MEDLINE and SCOPUS databases.

• Various metabolic, inflammatory, and hematologic markers were identified to be shared between frailty and sarcopenia.

• Negative association of albumin and hemoglobin with both these conditions was found.

• Interleukin 6 was found to be related to frailty and sarcopenia only in individuals aged < 75.

• Higher levels of tumor necrosis factor alpha were detected in community-dwelling older adults with frailty and sarcopenia vs their robust and non-sarcopenic counterparts.