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Biomarkers of exposure among U.S. adult cigar smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014)

Cancer Epidemiology, Biomarkers & Prevention Feb 14, 2019

Chang CM, et al. - Researchers used Wave 1 urinary biomarker data from 5,604 adults in the Population Assessment of Tobacco and Health (PATH) Study and compared biomarkers of nicotine and tobacco toxicants among cigar smokers and other groups. They assessed cigar-only smokers (all cigars and separately for traditional, cigarillo, and filtered cigars), cigarette-only smokers, dual cigar/cigarette smokers, and never-users of tobacco. Adjusting for sex, age, race/ethnicity, education and creatinine, they computed geometric mean ratios (GMR) comparing groups with never-users. Findings revealed comparability between daily cigar-only smokers and daily cigarette-only smokers in terms of some biomarkers, including NNAL (NNK metabolite) and CYMA (metabolite of acrylonitrile). They detected higher biomarker concentrations in daily filtered cigar-only smokers (n=7) vs daily traditional cigar-only smokers (n=12) and cigarillo-only smokers (n=24) in exploratory analyses. They noted similarities between daily smokers of each cigar type and exclusive cigarette smokers. Higher concentrations were observed for some biomarkers, specifically for daily filtered cigar-only smokers.

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