Greenberg JH, et al. - In this three-center prospective cohort study of children undergoing cardiopulmonary bypass, researchers investigated whether biomarkers of inflammation and kidney injury could predict AKI progression. They observed significant elevations in nine biomarkers on the first day of AKI in patients with than without AKI progression. Also, they noted that urine liver fatty acid binding protein (among injury biomarkers) and plasma IL-8 (among inflammatory biomarkers) had the highest discrimination for AKI progression. Results showed that plasma IL-8 could be used to improve clinical care and guide enrollment in therapeutic trials of AKI if validated in additional cohorts.