Biomarkers for the prediction of venous thromboembolism in critically ill COVID-19 patients
Thrombosis Research Sep 18, 2020
Dujardin RWG, Hilderink BN, Haksteen WE, et al. - Researchers undertook this retrospective cohort study to construct a prediction model for venous thromboembolism (VTE) in critically ill coronavirus disease 2019 patients (n = 127). D-dimer and C-reactive protein (CRP) were identified as the variables that were related to VTE in both univariate and multivariate analysis, with an AUC of 0.64 and 0.75, respectively. Findings demonstrated a high positive predictive value of elevated CRP and D-dimer for VTE in this patient population. Using these biomarkers, a prediction table was constructed that can assist clinicians in the timing of imaging in patients with suspected VTE. With a D-dimer > 15 together with a CRP > 280, the predicted likelihood of VTE was 98%.
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