Lee WF, Wu CY, Yang HY, et al. - In this retrospective chart review, researchers evaluated endothelial dysregulation related biomarkers in pediatric-onset systemic lupus erythematosus (pSLE) patient serum and illustrated its association with their clinical characteristics, laboratory parameters, and the overall disease activity. The study sample consisted of 118 pSLE patients and 40 age-matched healthy controls. According to findings, protein-associated endothelial dysregulation tends to be potent biomarkers for pSLE activity as well as affecting organs in patients with pSLE. These biomarkers can help to understand vascular pathogenesis and monitor disease.