Lim S, Li W, Kemper J, et al. - The performance of soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and the sFlt-1/PlGF ratio in predicting adverse outcomes in women with preeclampsia was systematically reviewed. Performing literature search in MEDLINE, EMBASE, CINAHL, Cochrane, Scopus, ClinicalTrials.gov, and Emcare databases from 1989 to March 2019, 3,194 articles were identified; 33 of these (n = 9,426 patients) were included. Findings suggest promising prognostic value of placental growth factor and sFlt-1/PlGF ratio for adverse outcomes in preeclampsia, however, their clinical utility is limited by study heterogeneity.