Comparing long-term results of percutaneous coronary intervention (PCI) with biodegradable polymer drug-eluting stents (BP-DES) vs durable polymer drug-eluting stents (DP-DES), similar rates of the composite outcome were noted in patients throughout the entire follow-up. At 1-year, the BP-DES group had lower rates of target lesion revascularization, which equalized within 5 years.

• Of 11,517 PCIs performed with second-generation DES, 8,042 procedures done using DP-DES and 3,475 using BP-DES were found.

• Primary outcome was defined as target lesion failure, the composite target lesion revascularization (TLR), target vessel myocardial infarction and death; and propensity score matching was employed to yield a well-balanced cohort.

• At 1 year, the primary outcome occurred in 8.3% vs 7.1%, and TLR rate was 3% vs 2% in patients with DP-DES and BP-DES, respectively.

• In patients with DP-DES and BP-DES, primary outcome occurred in 23.1% vs 23.4%, and TLR rate was 7.2% vs 6.5%, respectively, within 5 years.