Massera D, Xu S, Walker MD, et al. - In this involving 1,680 women from the population-based Cardiovascular Health Study, researchers explored the associations of osteocalcin (OC), a marker of bone formation, and C-telopeptide of type I collagen (CTX), a marker of bone resorption, with long-term incidence of hip fracture in older women. Using multivariable Cox models, the longitudinal connection of both markers with incidence of hip fracture was examined. Two hundred eighty-eight incident hip fractures occurred during a median follow-up of 12.3 years. CTX, but not OC, levels in postmenopausal women were associated with incident hip fracture, a relationship characterized by an inverted U-shape. These outcomes highlight the complex connection of bone turnover markers with the risk of hip fracture.