Nimer N, Choucair I, Wang Z, et al. - Experts aspired to explore whether or not specific bile acids (BAs) are correlated with the clinically relevant transition from nonalcoholic fatty liver (ie, simple steatosis) to non-alcoholic steatohepatitis (NASH), or enhanced progression of hepatic fibrosis, or genetic determinants of non-alcoholic fatty liver disease (NAFLD)/NASH. Among 102 sequential individuals undergoing a diagnostic liver biopsy, they investigated the correlations of a broad panel of BAs with distinct histopathological characteristics of NAFLD, the presence of NASH, and their connections with genetic variants linked to NAFLD and NASH. through the entire spectrum of NAFLD, plasma BA alterations were seen with several glycine conjugated forms of the BAs showing significant connections with higher grades of inflammation and fibrosis. Histopathological and genetic determinants of the transition from simple hepatic steatosis into NASH are correlated with circulating bile acid levels.