Zhou R, Leng T, Yang T, et al. - Since recent studies have shown that activation of ASIC1a (acid-sensing ion channel 1a) by tissue acidosis, a common characteristic of brain ischemia, plays a significant role in ischemic brain injury, researchers evaluated the effects of β-estradiol on acidosis-mediated and ischemic neuronal injury both in vitro and in vivo and explored the involvement of ASIC1a and its underlying mechanism. By Western blotting and quantitative real-time polymerase chain reaction, ASIC1a expression was detected. According to results, neuronal cell treatment with β-estradiol lowered cytotoxicity induced by acidosis. By suppressing ASIC1a protein expression and channel function, β-estradiol protects neurons from acidosis-mediated neurotoxicity and ischemic brain injury.