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Beta-blocker therapy is not associated with mortality after intracerebral hemorrhage

Acta Neurologica Scandinavica Sep 11, 2017

Sykora M, et al. - The effects of pre-admission therapy with beta-blockers (BB) on the mortality following spontaneous intracerebral hemorrhage (ICH) were investigated in this study. The clinicians found no association between pre-admission use of BB with mortality following ICH.

Methods
  • For this study, the clinicians designed a retrospectcive investigation.
  • In this study, they examined the Helsinki ICH Study database.

Results
  • The clinicians included 1013 patients with ICH in the analysis.
  • Patients taking BB reported the following features: they were significantly older, had a higher premorbid mRS score, had more DNR orders, and more comorbidities as atrial fibrillation, hypertension, diabetes mellitus, ischemic heart disease, and heart failure
  • No differences in in-hospital mortality (OR 1.1, 95% CI 0.8-1.7), 12-month mortality (OR 1.3, 95% CI 0.9-1.9), and 3-month mortality (OR 1.2, 95% CI 0.8-1.7) emerged after adjustment for age, pre-existing comorbidities, and prior use of antithrombotic and antihypertensive medications.
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