Reddy YNV, et al. - Researchers investigated whether pulmonary vasodilation during exercise in patients with heart failure with preserved ejection fraction (HFpEF) could be improved by inhaled β-adrenergic agonist albuterol, without increasing left heart filling pressures. They used high fidelity micromanometer catheters and expired-gas analysis to examine how resting and exercise hemodynamics in subjects with HFpEF (n=30) were altered by inhaled albuterol. Participants were randomized 1:1 to inhaled, nebulized albuterol or placebo. According to findings, pulmonary vascular reserve was improved with albuterol without worsening left heart congestion in patients with HFpEF.