Leite F, et al. - The present study is performed to search for the expression of adrenoceptors (AR) in circulatory immune cells and its correlation with anthropometric, endocrine/metabolic and inflammatory parameters in a well-characterized group of blood donors (BD) to establish: i) whether central obesity, a surrogate marker of abdominal fat mass, is related to variable AR expression in PBMCs and ii) the extent to which this relationship is clarified by anthropometric/metabolic/endocrine/inflammatory factors. PBMCs β2AR, underexpressed in centrally obese, are related to a better metabolic profile and demonstrated a protective role for the development of central obesity (CO). The discovery of β2AR as a new molecular marker of obesity subphenotypes in peripheral blood mononuclear cells (PBMCs) might contribute to elucidate the adrenergic immunomodulation of inflammatory obesity.