Benasi G, et al. - Researchers performed a systematic review and, when feasible, a meta-analysis of randomized controlled trials (RCT) which used benzodiazepines (BZD) as a monotherapy vs placebo, antidepressant drugs (AD), or both. Analysis of individual studies revealed that BZD were markedly more effective than placebo and as effective as tricyclic antidepressants (TCA) in more than half of the studies comparing BZD to TCA and/or placebo. Findings hereby indicate that in anxious depression, BZD are a therapeutic option and there are no indications that AD are preferable.