Nandalur KR, Colvin R, Walker D, et al. - This study’s findings demonstrate that elevating central gland volume, driven by benign prostate hyperplasia (BPH), is correlated with lower odds of significant prostate cancer (Pca), including multifocal disease, while peripheral zone (PZ) anatomic and histologic surrogate changes were noncontributory. According to the findings, the results support BPH impediment of global tumor growth predicted by a theoretical mechanobiological model. Researchers should further evaluate potential stabilizing factors for risk stratification and in consideration for BPH therapy.

• In this study, 405 patients who had undergone prostate MRI and biopsy and/or prostatectomy from January 2019 to January 2021 at our institution were distinguished.

• The multivariable analysis demonstrated that the higher CG volumes were at lower odds of ≥ GG2 disease (n = 227) (OR: 0.97, 95% CI 0.96–0.98, p < 0.0001), taking into account PZ volume (p = 0.18) and thickness (p = 0.70).

• There was an approximately 3% decrease in odds of ≥GG2 disease for every one cc increase in CG volume.

• They observed similar findings for multifocal disease (n = 180) (OR: 0.97, 95% CI 0.96–0.98, p < 0.0001).

• The findings revealed that ADC of the normal PZ was not significantly correlated with CG volume (p = 0.21) nor a predictor of disease (p = 0.49).