MacColl C, et al. - Through a retrospective review of pathology reports of 266 people with a diagnosis of benign papilloma on breast core biopsy, researchers intended to recognize risk factors correlated with the upgrade and discover the upgrade rate of non-atypical papillomas at their institution. Surgical resection was performed in 182 patients. The terminal surgical pathology reports of all individuals were reviewed and classified into one of two groups—benign or malignant. Twenty-one individuals had a final diagnosis of in situ or invasive carcinoma which led to an upgrade rate of 12%. For the upgrade, radiologically detected lesions with calcifications were at greater risk in comparison with lesions with no calcifications. Moreover, progressed patient age and lesion size greater than 0.5 cm was correlated with the upgrade to malignancy. Of all papillomas, routine surgical excision was not suggested. Younger individuals without high-risk characteristics may profit from clinical and radiologic follow-up alone. Further, accurate risk stratification would forbear low-risk women unnecessary surgery.