Gong Y, Wang P, Zhu Z, et al. - Via performing this meta-analysis, researchers examined the efficacy and safety of neoadjuvant intraperitoneal and systemic chemotherapy (NIPS)-combined surgery for gastric cancer (GC) patients with peritoneal metastasis. They included eight studies comprising 373 GC patients with peritoneal metastasis; 265 underwent NIPS-combined surgery and 109 with NIPS only. Outcomes support NIPS-combined surgical treatment as effective and safe for managing GC with peritoneal metastasis. NIPS-combined surgery than with NIPS only was correlated with significantly better survival. S-1 Joint intravenous paclitaxel and intraperitoneal paclitaxel vs other NIPS regimens resulted in significantly better survival. They observed a higher conversion rate, higher percentage of patients with R0 surgery, less severe adverse reactions to chemotherapy, and fewer postoperative complications in correlation to receipt of NIPS regimens.