Weiss BG, Anczykowski MZ, Flach S, et al. - In this retrospective case series, researchers assessed the oncological long-term result of individuals with pT1-pT2 pN1 squamous cell carcinoma (SCC) of the oral cavity, the oropharynx, and the hypopharynx without extracapsular spread (ECS) following a margin-negative surgical resection, who either received or did not receive postoperative (chemo)radiotherapy. For this investigation, they retrospectively assessed the oncological outcome of patients with pT1-pT2 pN1 SCC without ECS. All individuals had primary tumor resection that involved transoral laser microsurgery and neck dissection at an academic tertiary referral center. Of the 65 patients reported treated between 1986 and 2015, 21 received postoperative radiotherapy and 44 received surgical treatment alone. The group of patients seeking postoperative treatment demonstrated a significantly superior 5-year disease-specific and recurrence-free survival, as well as a higher local control rate. Data reported that the overall survival was 71.4% vs 62.6%. It was noted that the mean follow-up was 80.7 months. The authors discovered that individuals with locally circumscribed carcinomas and a single ipsilateral ECS-negative lymph node metastasis appear to benefit from postoperative radiotherapy.