Jadhav AP, Aghaebrahim A, Jankowitz BT, et al. - In patients presenting with wake-up stroke vs those presenting with witnessed onset or unwitnessed onset, researchers ascertained if the benefit of thrombectomy in late presenting acute stroke patients with imaging evidence of clinical-infarct mismatch is different. The primary outcome was the proportion of modified Rankin Scale score 0 to 2 at 90 days for the purposes of this investigation. To evaluate the link between outcome and mode of onset, univariable analysis and multivariable logistic regression was used. The study included all 206 enrolled patients. Mode of onset was not identified as a significant predictor of modified Rankin Scale score 0 to 2 at 90 days in univariable and multivariable analyses. The benefit of thrombectomy was similar regardless of the wake-up, unwitnessed, or witnessed mode of onset in patients with acute ischemic stroke presenting between 6 and 24 hours from time last seen well and harboring clinical-infarct mismatch.