Fabritius ML, et al. - This study appraised benefit and risk profile of pregabalin in postoperative pain management. Despite displaying a minimal opioid-sparing effect, pregabalin seemed to confer an increased risk for serious adverse events (SAEs). However, the Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-rated evaluations showed only moderate to very low quality of evidence. Overall, recommendations were against a routine use of pregabalin for postoperative pain treatment.