Jayaraman J, et al. - Via this prospective randomized double blinded study, researchers compared different techniques to guide accurate prediction of optimal central venous catheter (CVC) depth insertion before or during the procedure at the bedside. Participants were patients (n=180, aged between 18 to 65 years) needing central venous catheterization. Peres' formula method, Landmark technique and Intra atrial Electrocardiography (ECG) guided technique were used to perform the optimal depth of insertion of right internal jugular vein (IJV) catheter. Using carina as a landmark in post procedural chest radiograph, they compared the three techniques in terms of optimal positioning. In post procedure X ray, upto 1 cm above or below the carina was considered as the correct position of the catheter tip. For accurate central venous catheter tip positioning, comparable value of landmark guidance and ECG guidance was evident when CVCs were placed through right IJV. The least accurate method was formula based technique, which led to over insertion of CVCs.