Bareham CA, Roberts N, Allanson J, et al. - In view of large cross-sectional studies establishing the diagnostic and prognostic value of functional brain networks measured using high-density electroencephalography (hdEEG), researchers here examined the utility of hdEEG to prognosticate long-term behavioral outcome, utilizing longitudinal data obtained from a cohort of prolonged disorder of consciousness (pDOC) patients assessed systematically with resting hdEEG and the Coma Recovery Scale-Revised (CRS-R) at the bedside over a period of 2 years. Findings revealed strongest correlation of theta power and alpha clustering with changes in CRS-R scores. EEG combined with CRS-R led to an improvement in the predictive power of future CRS-R scores. In terms of prognostic power, early changes in EEG were superior to early changes in CRS-R. They suggest feasibility of regular and repeated bedside EEG and its clinical utility for pDOC.